Which of the following is a potential adverse reaction of NSAIDs?

The potential adverse reaction of NSAIDs that is most important to highlight is gastric irritation and bleeding. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, are known to inhibit the production of prostaglandins, which play a protective role in maintaining the gastric mucosal barrier. By reducing these protective prostaglandins, NSAIDs can lead to increased acidity in the stomach and a higher likelihood of gastric irritation. This irritation can progress to more serious complications, such as gastric ulcers and bleeding, which are significant concerns for patients using these medications, particularly in individuals with a history of gastrointestinal issues or those taking higher doses over extended periods. Therefore, recognizing this risk is crucial in patient care and monitoring when administering NSAIDs.