What serious adverse reaction is associated with quinolones?

Study for the HFHS Inpatient Nursing Pharmacology Test. Use flashcards and multiple choice questions with hints and explanations. Prepare effectively for your exam!

Quinolones, also known as fluoroquinolones, are a class of antibiotics used to treat a variety of bacterial infections. One significant adverse reaction associated with this class of medications is increased intracranial pressure (ICP). This can occur especially in individuals who are predisposed to central nervous system complications or who have a history of seizures.

Increased ICP can lead to symptoms such as headache, nausea, vomiting, altered mental status, and in severe cases, may cause visual disturbances or seizures. The mechanism by which quinolones may contribute to increased ICP is not fully understood, but it is thought that they can affect the central nervous system by potentially interfering with GABA receptors, which play a crucial role in neuronal excitability and regulation.

Other potential adverse effects of quinolones, such as nausea, fatigue, or orthostatic hypotension, do occur but are typically not as severe or life-threatening as the risk of increased ICP. While nausea and fatigue are common and can be bothersome, they do not have the same level of urgency or potential for serious health risks as increased ICP, particularly for patients with underlying vulnerabilities. Orthostatic hypotension may occur but is also generally manageable and not classified as a serious adverse reaction compared to the

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