What patient education regarding NSAIDs is important to prevent gastric irritation?

Taking NSAIDs with food or milk is important because it helps to buffer the stomach lining against the irritation that these medications can cause. NSAIDs, such as ibuprofen and naproxen, inhibit the production of prostaglandins, which play a protective role in the stomach's mucosal lining. Without sufficient prostaglandins, the stomach becomes more susceptible to irritation and the development of ulcers or gastritis. By consuming them with food or milk, the patient can reduce the likelihood of these adverse gastrointestinal effects, as the presence of food provides a protective barrier and can help to minimize the direct contact of the NSAID with the stomach lining.

Other options suggest taking the medication in a way that could potentially increase gastric irritation. Taking NSAIDs on an empty stomach may lead to more pronounced discomfort and increases the chance of developing gastric issues. Only taking them when experiencing pain does not address the overall risk of irritation from regular use, and limiting intake to once daily might not provide sufficient analgesia or anti-inflammatory effects, potentially leading to increased pain and further use of the medication without protective measures.