What can influence drug metabolism aside from age and weight?

Drug metabolism can be significantly influenced by a variety of factors, and one important consideration is the impact of ethnicity and environmental factors. Ethnicity can affect metabolic enzymes due to genetic variations that are more prevalent in certain populations. For example, individuals from different ethnic backgrounds might express different isoforms of cytochrome P450 enzymes, which play a crucial role in drug metabolism.

Environmental factors such as exposure to certain chemicals, lifestyle choices, and even geographic location can also play a significant role. For instance, substances in the environment like pollutants or dietary factors may induce or inhibit metabolic enzymes, thereby altering the metabolism of various medications.

Recognizing the importance of both genetic diversity and environmental influences can help healthcare providers anticipate variations in drug responses among different patient populations. This understanding is essential for optimizing pharmacotherapy and minimizing adverse effects.