Patients taking estrogens should report which symptom?

Patients taking estrogens should report unusual vaginal bleeding because this can be a significant symptom indicating potential complications associated with estrogen therapy. Unusual or abnormal bleeding may suggest issues such as endometrial hyperplasia or cancer, particularly in postmenopausal women who are not on a progestin. Estrogens can stimulate the growth of the endometrial lining, and any unexpected bleeding should be evaluated promptly to rule out serious conditions.

Although increased appetite, nausea, and fatigue can also occur with estrogen use – often as common side effects – they are generally less alarming than unusual vaginal bleeding. These other symptoms may not indicate severe complications and are more manageable or typical in the context of hormone therapy. Thus, monitoring for abnormal bleeding is critical for patient safety and effective management of potential risks associated with estrogen use.